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Ketamine is an anaesthetic agent which has been used safely for general anaesthesia for many decades. Recently it has been demonstrated in scientific studies that at low doses it has a rapid and robust antidepressant effect. The drug works by targeting the glutamate system in the brain, which is involved in mood regulation. It is widely gaining acceptance in the USA, Europe, and India as a treatment for people with acute depression and feeling suicidal, chronic depression or treatment-resistant depression.